Komentarze do: Deficyty witaminy D w zespole Downa prowadzą do dysfunkcji metabolicznych https://www.zespoldowna.info/deficyty-witaminy-d-w-zespole-downa-prowadzi-do-dysfunkcji-metabolicznych.html Fri, 25 Sep 2026 21:20:10 +0000 hourly 1 https://wordpress.org/?v=4.1.42 Autor: Michał https://www.zespoldowna.info/deficyty-witaminy-d-w-zespole-downa-prowadzi-do-dysfunkcji-metabolicznych.html#comment-352606 Tue, 30 Dec 2025 19:27:26 +0000 https://www.zespoldowna.info/?p=108930#comment-352606 Ciekawostka o obnizaniu stresu oksydacyjnego poprzez wyciąg z propolisu:

Nrf2 ActivatorsNrf2 transcriptionally induces antioxidant enzymes (HO-1, NQO1, GCLC for glutathione) via ARE elements; in DS, BACH1 overexpression suppresses this, amplifying oxidative stress.��Caffeic acid phenethyl ester (CAPE)Mechanism: Natural propolis derivative; disrupts Keap1-Nrf2 binding, promoting Nrf2 stabilization, nuclear translocation, and upregulation of antioxidant genes in lymphocytes and neural models.� In DS lymphoblastoid cell lines (LCLs), CAPE ameliorates redox imbalance by restoring Nrf2 activity against BACH1.�DS relevance: Specifically tested in DS cells, showing Nrf2 nuclear shift and antioxidant recovery without toxicity noted.�

Scientific Papers on CAPE Mechanism and DSCAPE restores BACH1/Nrf2 in DS cells: https://www.sciencedirect.com/science/article/abs/pii/S0891584922001010 �CAPE pharmacological review: https://pmc.ncbi.nlm.nih.gov/articles/PMC9880688/ �CAPE neuroprotection: https://pmc.ncbi.nlm.nih.gov/articles/PMC8762179/ �

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