Komórki macierzyste dla naprawy chromosomów: kolejny przełom w medycynie!?

Listopad 21, 2014 by
Kategoria: Wiedza o Zespole Downa

Czytam ten oryginalny tytuł: Stem Cells to Repair Broken Chromosomes: Medicine’s Next Big Thing?, czyli komórki macierzyste naprawiają uszkodzony chromosom i zamiast się cieszyć z postępu, zastanawiam się kto na to pozwoli.

W skrócie: wymyślono metodę wytwarzania komórek macierzystych leczących choroby genetyczne poprzez ”ponowne zaprogramowanie” komórek już istniejące. Zakończono testy w tzw. kulturach laboratoryjnych, ale sam wniosek jaki pojawił się w tym raporcie, że może on prowadzić do leczenia wad genetycznych brzmi niezwykle.

“A new way to correct a defective "ring chromosome" through cellular reprogramming has the promise to eliminate abnormalities that cause genetic disorders”

http://www.wndu.com/home/headlines/New-DNA-discovery-could-lead-to-chromosome-therapies-in-the-future-283076941.html?device=phone&c=y

MEDICAL BREAKTHROUGHS
RESEARCH SUMMARY

TOPIC: Stem Cells to Repair Broken Chromosomes: Medicine’s Next Big Thing?
REPORT: MB #3854

BACKGROUND: Gene mutations are what cause genetic disorders. They can either be an inherited trait from parents, or can occur during a persons’ lifetime. There are three types of genetic disorders: single-gene disorders, such as sickle cell anemia, chromosomal disorders, such as Down syndrome, and complex disorders, such as colon cancer. Knowing a families’ health history can help pre-screen patients who are concerned about genetic disorders. Common diseases that run in families are heart disease, cancer, asthma, and diabetes. More rare diseases can include hemophilia, and cystic fibrosis. The U.S. Surgeon General’s Family History Initiative is a national public health campaign to motivate Americans to learn more about their family health history.
(Source: http://www.nlm.nih.gov/medlineplus/geneticdisorders.html, http://www.genome.gov/19016938)

TREATMENT: Genetic makeup determines how your body breaks down certain medicines; genetic testing studies the liver enzymes of an individual and how they break down and remove medicines from the body. The testing can be applied to finding the right dosage of a certain medicine to administer for an illness. Treating genetic disorders have some setbacks. Custom medications may be more costly, and not accessible to everyone who may need that treatment. Each genetic disease requires specific and usually personalized treatment – for a comprehensive list of disorders and their respective treatments, visit http://ghr.nlm.nih.gov/BrowseConditions.
(Source: http://www.genome.gov/19016938)

NEW DISCOVERY: A new way to correct a defective "ring chromosome" through cellular reprogramming has the promise to eliminate abnormalities that cause genetic disorders. An international team of geneticists from Ohio, California and Japan, led by Anthony Wynshaw-Boris, MD, PhD, researched and discovered how to reprogram a patient’s skin cells into induced pluripotent stem cells (iPSCs). The technique was developed by Shinya Yamanaka, MD, PhD, co-author of the research study, at Kyoto University. The reprogramming technique has only been applied to cells in cultures, not people. Correcting structurally abnormal chromosomes is the next step for the research team, which would cover a broader variety of severe birth defects. The hope is to form a ring chromosome from the abnormal chromosome and applying the reprogramming technique.
(Source: http://casemed.case.edu/newscenter/news-release/newsrelease.cfm?news_id=193, http://case.edu/think/spring2014/fixing-defective-chromosomes.html#.VDaqlfldU1I)

FOR MORE INFORMATION ON THIS REPORT, PLEASE CONTACT:

Jeannette Spalding
Scientific Writer/Editor
Case Western Reserve University School of Medicine
(216) 368-3004
[email protected]

Komentarze

1 Komentarz do “Komórki macierzyste dla naprawy chromosomów: kolejny przełom w medycynie!?”
  1. MartaO. pisze:

    Ojtam ojtam… dopiero na bakteriach testuja… a i tak w sumie nie wiadomo jak to sie uda. O tych komorkach macierzystych to glosno jest wszedzie, znaczy sie dobra kasa. Mnie sie spodobal ostatni news, ze facet nie chodzacy po wypadku zostal uleczony przez wlasne komorki glejowe, ktore mu przeszczepili z mozgu do kregoslupa i tam one zaczely sie namnazac i leczyc uszkodzona czesc kregoslupa. To jest dopiero rewelka.
    Pozdr.
    M.

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